Novel hit of DPP-4Is as promising antihyperglycemic agents with dual antioxidant/anti-inflammatory effects for type 2 diabetes with/without COVID-19Research article Published on 2022-11-012022-10-05 Journal: Bioorganic chemistry [Category] SARS, 신약개발, [키워드] activities activity addition Anti-inflammatory antioxidant Cell Co-receptor consequence COVID-19 CRP derivatives DPPH Effect evaluated IL-6 infections molecular docking not correlated novel OGT Patient Pyrimidinones question raised SARS-CoV-2 screened small molecule drug tested therapy Treatment type 2 diabete type 2 diabetes [DOI] 10.1016/j.bioorg.2022.106092 [Article Type] Research article
Habituating to pandemic anxiety: Temporal trends of COVID-19 anxiety over sixteen months of COVID-19Randomized Controlled Trial Published on 2022-09-152022-10-05 Journal: Journal of affective disorders [Category] COVID19(2023년), SARS, 임상, [키워드] affected Anxiety association BASIL Brazil Burnout COVID-19 deaths dimension distress fear Health implication individual influence Intervention Mental mental health not correlated pandemic Pandemic anxiety participated physical preventive measure putative mechanism randomized clinical trial reduced Result Temporal Worry Worry. [DOI] 10.1016/j.jad.2022.06.077 PMC 바로가기 [Article Type] Randomized Controlled Trial
SARS-CoV-2 Omicron BA.1 variant breakthrough infections in nursing home residents after an homologous third dose of the Comirnaty® COVID-19 vaccine: Looking for correlates of protectionComirnaty® COVID-19 백신의 동종 3차 접종 후 요양원 거주자의 SARS-CoV-2 Omicron BA.1 변이형 돌발성 감염: 보호 상관 관계 찾기Observational Study Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료제, [키워드] anti-RBD Anti-spike anti-spike antibodies antibody blood levels booster dose both groups Breakthrough infection CD4 CD8 chemiluminescent immunoassay Comirnaty® COVID-19 vaccine comparable COVID-19 COVID-19 vaccine cytokine detectable dose evaluated female flow cytometry Frequency homologous immune parameter Immunological response in both groups individual level Infection intracellular cytokine staining investigated likelihood median median age Neutralization assay Neutralizing Neutralizing antibodies neutralizing antibody not correlated nursing home nursing home residents observational study omicron Omicron variant participant Peripheral blood predict Pseudotyped virus quantified reactive Receptor binding domain risk SARS-CoV-2 SARS-CoV-2 Omicron variant SARS-CoV-2 spike SARS-CoV-2-S spike spike-reactive T cells. subsequent symptomatic T cell T cells total antibody uninfected participant Vaccine variant were measured [DOI] 10.1002/jmv.27867 PMC 바로가기 [Article Type] Observational Study
Detection of SARS-CoV-2 in exhaled air using non-invasive embedded strips in masks마스크에 비침습적 내장 스트립을 사용하여 호기에서 SARS-CoV-2 감지Article Published on 2022-08-012022-09-11 Journal: American journal of infection control [Category] SARS, 치료기술, [키워드] alcohol approach asymptomatic individual Asymptomatic individuals comparable conditions COVID-19 detect detection Detection limit face Face masks feasibility Frequently Health individual individuals infected individuals Infection Infectious virus invasive Mask Masks nasal swab Non-invasive not correlated pandemic Personal protective equipment platform polyvinyl alcohol Protective qRT-PCR qRT-PCR analysis qRT-PCR analysis. Quantitative RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA secretion symptom status symptomatic individual tested Viral load viral loads Viral RNA virus vRNA Xerostomia [DOI] 10.1016/j.ajic.2022.01.010 PMC 바로가기 [Article Type] Article
Definition of factors associated with negative antibody response after COVID-19 vaccination in patients with hematological diseases혈액 질환 환자에서 코로나19 백신 접종 후 항체 음성 반응과 관련된 요인 정의Article Published on 2022-08-012022-09-12 Journal: Annals of Hematology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] active treatment addition age Analysis antibody Antibody Response AstraZeneca BNT162b2 BTK inhibitor CML Combination Concentration correlated COVID-19 COVID-19 vaccination Definition demonstrated disease Efficacy Factor had no hematological Hematological diseases/disorders high mortality knowledge leukemia lymphoid median age Moderna mRNA-1273 naïve negative antibody response neoplasm Neoplasms not correlated other disease other diseases Patient patient cohort positive positive response reduced response to vaccination ruxolitinib SARS-CoV-2 seroconversion. significantly single-center study Spike protein Surveillance the SARS-CoV-2 therapy treated Treatment vaccination was performed were measured women [DOI] 10.1007/s00277-022-04866-z PMC 바로가기 [Article Type] Article
Seizure control during the COVID-19 pandemic: Correlating Responsive Neurostimulation System data with patient reportsResearch article Published on 2022-07-012022-10-05 Journal: Clinical neurophysiology : official journal of the [Category] 치료기술, [키워드] Anxiety change conducted coronavirus disease-2019 correlated correlation COVID-19 COVID-19 pandemic Depression epilepsy Frequency increase in Increased Long episode medication mental health MOST neurostimulation no correlation not correlated objective pandemic Patient positively correlated reported Result risk factor RNS Seizure Seizures Significance Sleep disturbance Stress Stressor stressors System telephone survey Weekly were used [DOI] 10.1016/j.clinph.2022.05.003 [Article Type] Research article
High Incidence of SARS-CoV-2 Variant of Concern Breakthrough Infections Despite Residual Humoral and Cellular Immunity Induced by BNT162b2 Vaccination in Healthcare Workers: A Long-Term Follow-Up Study in Belgium의료 종사자의 BNT162b2 백신 접종으로 유도된 잔류 체액 및 세포 면역에도 불구하고 우려되는 돌발 감염의 SARS-CoV-2 변종 높은 발생: 벨기에의 장기 추적 연구Clinical Trial Published on 2022-06-092022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response Alpha analyzed antibody B cell B cells Belgium binding BNT162b2 BNT162b2 vaccine Breakthrough infection breakthrough infections caused CD4 CD8 Cellular immune response cellular immunity circulating concern coronavirus COVID-19 delta variant delta VoCs domain Follow-up functional healthcare healthcare worker Healthcare workers humoral immune responses immunoassays in vitro incidence individual induced initiated interferon interferon-γ investigated Long-term follow-up Long-term monitoring mitigate MONITOR neutralization not correlated performed pseudovirus reduced reported residual respiratory SARS-CoV-2 SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells serology severe acute respiratory syndrome Coronavirus single-center subject symptomatic T cells Trial vaccination Vaccine-induced immunity variant variants variants of concern variants of concern. was determined were assessed [DOI] 10.3390/v14061257 PMC 바로가기 [Article Type] Clinical Trial
Up-regulated serum levels of interleukin (IL)-17A and IL-22 in Egyptian pediatric patients with COVID-19 and MIS-C: Relation to the disease outcomeCOVID-19 및 MIS-C가 있는 이집트 소아 환자의 인터루킨(IL)-17A 및 IL-22의 상향 조절된 혈청 수준: 질병 결과와의 관계Article Published on 2022-06-012022-09-11 Journal: Cytokine [Category] COVID19(2023년), SARS, 바이오마커, [키워드] age ALT antimicrobial peptide antimicrobial peptides ARDS cellular children contribute COVID-19 CRP D-dimer died dimer elevated ELISA epithelial cell epithelial cells ferritin healthy control IL-17A IL-22 Increased infections Inflammatory Inflammatory marker inflammatory markers Interleukins LDH Level lymphopenia MIS-C MIS–C neutropenia neutrophilia not correlated outcome pathology Pathways Patient patients patients with COVID-19 patients with SARS-CoV-2 Pediatric patient peptides Protective relation Sample size SARS-CoV-2 SARS-CoV-2. serum serum ferritin level Serum level serum levels signaling pathways significantly higher stimulate syndrome synergistic synergistic action the disease thrombocytopenia up-regulated were measured with COVID-19 [DOI] 10.1016/j.cyto.2022.155870 PMC 바로가기 [Article Type] Article
Seropositivity and neutralising antibodies at six months after BNT162b2 vaccination in patients with solid tumours고형암 환자에서 BNT162b2 접종 후 6개월째 혈청양성 및 중화항체Article Published on 2022-06-012022-09-12 Journal: European journal of cancer (Oxford, England : 1990 [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Analysis Antibody Response anticancer Blood BNT162b2 BNT162b2 vaccine Cancer collected comparable Control controls COVID-19 dose doses evaluated follow-up study health-care healthy controls IgG increased risk initial lymphocyte Lymphocyte count median neutralising antibody neutrophil count not correlated Patient Patients with cancer Predictive predictor Prospective Study RBD reported SARS-CoV-2 SARS-CoV-2. seropositive individuals Seropositivity severe coronavirus disease solid tumour the receptor-binding domain therapy titre titres Treatment vaccination vaccine dose were measured [DOI] 10.1016/j.ejca.2022.03.013 PMC 바로가기 [Article Type] Article
Monitoring respiratory mechanics by oscillometry in COVID-19 patients receiving non-invasive respiratory supportObservational Study Published on 2022-03-212022-10-05 Journal: PLoS ONE [Category] 임상, 치료기술, [키워드] acute respiratory distress Admission affected ARDS changes in Comorbidities Comorbidity complementary COVID 19 patient COVID 19 patients COVID-19 patient COVID-19 patients Deterioration discharge evaluate feasibility feasible hospital identify increasingly information intensive care unit invasive ventilation Italy less lung mechanics management Measures moderate-severe monitoring more difficult NIV Non-invasive respiratory support not correlated Oxygenation parameter Patient patients physiological pilot study receiving recruited respiratory Respiratory mechanics syndrome Treatment Trieste university Ventilation [DOI] 10.1371/journal.pone.0265202 PMC 바로가기 [Article Type] Observational Study